Research Assistant (CVMD/MH)

Job Description The Cardiovascular and Metabolic Disorders (CVMD) Programme houses state-of-the-art technologies for profiling mitochondrial function and metabolic adaptations in human patients and other model organisms and undertakes translational and clinical research in cardiovascular and metabolic disorders. Dr. Matthew Hirschey's laboratory has a long-standing focus on uncovering the fundamental mechanisms of metabolism and hormone signaling in normal physiology and disease, with a current emphasis on hepatocellular carcinoma (HCC). Using cutting-edge genomic and metabolomic methods, the group seeks to identify new regulators and pathways governing metabolic rewiring and endocrine control in liver cancer, and to discover therapeutic targets relevant to HCC and related cardiometabolic disorders. The selected candidate will perform a variety of functions related to research under the supervision of the Principal Investigator or his/her designate, including but not limited to the following: • Perform experimental work and support all aspects of the research project, including in vivo studies using mouse models of HCC, hepatocyte and liver cancer cell culture, and molecular, biochemical, and histological analyses of liver tissues. • Accurately monitor, document, and report experimental data and research findings, including maintaining detailed electronic laboratory notebooks, tracking animal cohorts and tumour progression, and preparing samples for downstream metabolomic, proteomic, or transcriptomic analyses. • Analyse and interpret experimental data and contribute to oral presentations and written outputs, including scientific reports, literature reviews, figures, and manuscript preparation for publication. • Support laboratory operations and ensure compliance with safety and regulatory requirements, including maintenance of reagents and animal colonies, adherence to LMPRS, AIMS, and Singapore Poisons Act guidelines, and provision of technical support to team members. • Establish laboratory management procedures to maintain high efficiency and productivity of the laboratory. • Contribute to project management, presentations and publications of research work, including supporting timelines across collaborators, presenting updates at lab and programme meetings, and assisting with grant and manuscript preparation. • Perform other related duties incidental to the work described therein. Job Requirements • Bachelor's or Master's degree in Sciences/Life Sciences with at least 2 years of relevant research experience. • Strong hands-on experience in rodent-based animal studies is essential, and additional expertise in molecular techniques and cell culture will be highly valued. • Demonstrated strong knowledge and hands-on expertise in supporting a broad range of research activities, including rodent handling and procedures, molecular biology, protein biochemistry, cellular assays, mammalian tissue culture, and histology, as well as sample preparation for genomics/metabolomics and rigorous data documentation/analysis. • Able to undertake independent research progressively. • A team player who can prioritise, multi-task and work collaboratively in a diverse workforce. • RCULA certification will be an advantage. We regret that only shortlisted candidates will be notified.